| Short Description : | Recombinant-Human IPP-1/PPP1R1A-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications: | SDS-PAGE |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Concentration: | 1 mg/mL |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1mM PMSF, 1mM EDTA, 10% Glycerol |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PPP1R1A |
| Gene ID: | 5502 |
| Uniprot ID: | PPR1A_HUMAN |
| Accession Number: | NP_006732.3 |
| Immunogen: | Human |
| Immunogen Region: | 1-171aa |
| Immunogen Sequence: | MEQDNSPRKI QFTVPLLEPH LDPEAAEQIR RRRPTPATLV LTSDQSSPEI DEDRIPNPHL KSTLAMSPRQ RKKMTRITPT MKELQMMVEH HLGQQQQGEE PEGAAESTGT QESRPPGIPD TEVESRLGTS GTAKKTAECI PKTHERGSKE PSTKEPSTHI PPLDSKGANS V |
| Post Translational Modifications | Phosphorylation of Thr-35 is required for activity. |
| Function | Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. |
| Protein Name | Protein Phosphatase 1 Regulatory Subunit 1aProtein Phosphatase Inhibitor 1I-1Ipp-1 |
| Database Links | |
| Cellular Localisation | |
| Alternative Protein Names | Protein Phosphatase 1 Regulatory Subunit 1a proteinProtein Phosphatase Inhibitor 1 proteinI-1 proteinIpp-1 proteinPPP1R1A proteinIPP1 protein |
Information sourced from Uniprot.org