| Function | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS13 is part of the integrator tail module and acts as a platform for the recruitment of transcription factors at promoters. At prophase, mediates recruitment of cytoplasmic dynein to the nuclear envelope, a step important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. |
| Protein Name | Integrator Complex Subunit 13Cell Cycle Regulator Mat89bb HomologGerm Cell Tumor 1Protein Asunder HomologSarcoma Antigen Ny-Sar-95 |
| Database Links | Reactome: R-HSA-6807505 |
| Cellular Localisation | NucleusCytoplasmNuclear Location Is Required For Recruitment Of Dynein Motors To Nuclear Envelope At G2/M |
| Alternative Protein Names | Integrator Complex Subunit 13 proteinCell Cycle Regulator Mat89bb Homolog proteinGerm Cell Tumor 1 proteinProtein Asunder Homolog proteinSarcoma Antigen Ny-Sar-95 proteinINTS13 proteinASUN proteinC12orf11 proteinGCT1 protein |
Information sourced from Uniprot.org
