Human Interleukin-18 Binding Protein (IL-18BP) protein (Recombinant) (STJP000301)
SPECIFICATIONS
HostHEK293
ConjugationUnconjugated
ImmunogenOptimized DNA sequence encoding Human Interleukin-18 Binding Protein (IL-18BP) mature chain fused to an C-terminal polyHis tag was expressed in HEK cells. NA
General Information
| Short Description | Recombinant-Human Interleukin-18 Binding Protein (IL-18BP)-protein was developed from hek293. For use in research applications. |
| Host | HEK293 |
| Note | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | 0.2 Mu m filtered PBS solution. |
| Storage Instruction | Can be stored in working aliquots atΒ°C-Β°C C for one month, or at-20Β°C C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than.1 ng/Β΅g (1EU/Β΅g). NA |
| Immunoreactivity | The activity of recombinant Interleukin-18 Binding Protein was determined by the ability to bind IL-18 in functional ELISA. NA |
Target Information
| Gene Symbol | IL18BP |
| Gene ID | 10068 |
| Uniprot ID | I18BP_HUMAN |
| Immunogen | Optimized DNA sequence encoding Human Interleukin-18 Binding Protein (IL-18BP) mature chain fused to an C-terminal polyHis tag was expressed in HEK cells. NA |
| Immunogen Region | Mature chain |
| Immunogen Sequence | MTMRHNWTPD LSPLWVLLLC AHVVTLLVRA TPVSQTTTAA TASVRSTKDP CPSQPPVFPA AKQCPALEVT WPEVEVPLNG TLSLSCVACS RFPNFSILYW LGNGSFIEHL PGRLWEGSTS RERGSTGTQL CKALVLEQLT PALHSTNFSC VLVDPEQVVQ RHVVLAQLWA GLRATLPPTQ EALPSSHSSP QQQG NA |
Additional Info
| Tissue Specificity | Strongly expressed in heart, lung, placenta and spleen. |
| Post Translational Modifications | N- and O-glycosylated. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Ser-53: HexHexNAc (major) and Hex2HexNAc2 (minor). N-glycan heterogeneity at Asn-103: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major) and Hex6HexNAc5 (minor).N-glycan at Asn-147: dHex1Hex5HexNAc4. |
| Function | Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. |
| Protein Name | Interleukin-18-Binding ProteinIl-18bpTadekinig-Alfa |
| Database Links | Reactome: R-HSA-9008059Reactome: R-HSA-9012546 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Interleukin-18-Binding Protein proteinIl-18bp proteinTadekinig-Alfa proteinIL18BP protein |
Information sourced from Uniprot.org