| Post Translational Modifications | Tyrosine phosphorylated by the members of the SRC family after exposure to a diverse array of extracellular stimuli such as cytokines, growth factors, antibodies, chemokines, integrin ligands and hypertonic and oxidative stress. Phosphorylated upon IgG receptor FCGR2B-binding. |
| Function | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. |
| Protein Name | Phosphatidylinositol 3 -4 -5-Trisphosphate 5-Phosphatase 1Inositol Polyphosphate-5-Phosphatase DInositol Polyphosphate-5-Phosphatase Of 145 KdaSip-145Phosphatidylinositol 4 -5-Bisphosphate 5-PhosphataseSh2 Domain-Containing Inositol 5'-Phosphatase 1Sh2 Domain-Containing Inositol Phosphatase 1Ship-1P150shipHp51cn |
| Database Links | Reactome: R-HSA-1660499Reactome: R-HSA-1855204Reactome: R-HSA-202424Reactome: R-HSA-210990Reactome: R-HSA-912526Reactome: R-HSA-9680350 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinMembrane RaftCytoskeletonMembraneTranslocates To The Plasma Membrane When ActivatedTranslocation Is Probably Due To Different Mechanisms Depending On The Stimulus And Cell TypeTranslocates From The Cytoplasm To Membrane Ruffles In A Fcgr3/Cd16-Dependent MannerColocalizes With Fc-Gamma-Riib Receptor (Fcgr2b) Or Fcgr3/Cd16 At Membrane RufflesTyrosine Phosphorylation May Also Participate In Membrane Localization |
| Alternative Protein Names | Phosphatidylinositol 3 -4 -5-Trisphosphate 5-Phosphatase 1 proteinInositol Polyphosphate-5-Phosphatase D proteinInositol Polyphosphate-5-Phosphatase Of 145 Kda proteinSip-145 proteinPhosphatidylinositol 4 -5-Bisphosphate 5-Phosphatase proteinSh2 Domain-Containing Inositol 5'-Phosphatase 1 proteinSh2 Domain-Containing Inositol Phosphatase 1 proteinShip-1 proteinP150ship proteinHp51cn proteinINPP5D proteinSHIP proteinSHIP1 protein |
Information sourced from Uniprot.org
