Human IL5 protein (Recombinant) (N-His) (STJP003703)

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STJP003703
£328.50 - £1,437.50
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human IL5-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: IL5
Gene ID: 3567
Uniprot ID: IL5_HUMAN
Immunogen Region: Ile20-Ser134
Immunogen: Homo sapiens (Human)
Function Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.
Protein Name Interleukin-5
Il-5
B-Cell Differentiation Factor I
Eosinophil Differentiation Factor
T-Cell Replacing Factor
Trf
Database Links Reactome: R-HSA-512988
Reactome: R-HSA-5673001
Reactome: R-HSA-912526
Cellular Localisation Secreted
Alternative Protein Names Interleukin-5 protein
Il-5 protein
B-Cell Differentiation Factor I protein
Eosinophil Differentiation Factor protein
T-Cell Replacing Factor protein
Trf protein
IL5 protein

Information sourced from Uniprot.org

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