| Short Description : | Recombinant-Human IL34-C-His protein was developed from mammalian cells for the region C-His. For use in research applications. |
| Applications: | ELISA/Immunogen/SDS-PAGE/WB |
| Host: | Mammalian Cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Dilution Range: | Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | IL34 |
| Gene ID: | 146433 |
| Uniprot ID: | IL34_HUMAN |
| Immunogen: | Homo sapiens (Human) |
| Immunogen Region: | Asn21-Pro242 |
| Function | Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. |
| Protein Name | Interleukin-34Il-34 |
| Database Links | Reactome: R-HSA-449836Reactome: R-HSA-9680350 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Interleukin-34 proteinIl-34 proteinIL34 proteinC16orf77 protein |
Information sourced from Uniprot.org