Post Translational Modifications | N-glycosylated. |
Function | Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro. |
Protein Name | Interleukin-31 Receptor Subunit AlphaIl-31 Receptor Subunit AlphaIl-31r Subunit AlphaIl-31r-AlphaIl-31raCytokine Receptor-Like 3Glm-RHglm-RGp130-Like Monocyte ReceptorGp130-Like ReceptorZcytor17 |
Database Links | Reactome: R-HSA-6788467 |
Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinPresynaptic Cell MembraneCell ProjectionAxon |
Alternative Protein Names | Interleukin-31 Receptor Subunit Alpha proteinIl-31 Receptor Subunit Alpha proteinIl-31r Subunit Alpha proteinIl-31r-Alpha proteinIl-31ra proteinCytokine Receptor-Like 3 proteinGlm-R proteinHglm-R proteinGp130-Like Monocyte Receptor proteinGp130-Like Receptor proteinZcytor17 proteinIL31RA proteinCRL3 proteinGPL proteinUNQ6368 proteinPRO21073 proteinPRO21384 protein |
Information sourced from Uniprot.org