Human IL24 protein (Recombinant) (N-His) (STJP005275)

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STJP005275
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human IL24-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: IL24
Gene ID: 11009
Uniprot ID: IL24_HUMAN
Immunogen Region: Gln52-Leu206
Immunogen: Homo sapiens (Human)
Post Translational Modifications Glycosylated. Ubiquitination at Lys-122 promotes proteasomal degradation.
Function Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis. Possesses antiviral functions and induces the type I interferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1. Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal. In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2.
Protein Name Interleukin-24
Il-24
Melanoma Differentiation-Associated Gene 7 Protein
Mda-7
Suppression Of Tumorigenicity 16 Protein
Database Links Reactome: R-HSA-8854691
Cellular Localisation Secreted
Alternative Protein Names Interleukin-24 protein
Il-24 protein
Melanoma Differentiation-Associated Gene 7 Protein protein
Mda-7 protein
Suppression Of Tumorigenicity 16 Protein protein
IL24 protein
MDA7 protein
ST16 protein

Information sourced from Uniprot.org

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