Human IL21 protein (Recombinant) (Tag free) (STJP014695)

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STJP014695-100
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Short Description :Recombinant-Human IL21-Tag free protein was developed from e.coli and has a target region of Tag free. For use in research applications.
Applications:ELISA/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Dilution Range:Reconstitute in sterile water for a stock solution.
Formulation:Lyophilized from a 0.22 Mu m filtered solution in 20mM PB, 150mM NaCl, pH 7.4.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:< 0.01 EU/µg as determined by LAL test.
Gene Symbol:IL21
Gene ID:59067
Uniprot ID:IL21_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Gln30-Ser162
Function Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Protein Name Interleukin-21
Il-21
Za11
Database Links Reactome: R-HSA-9020958
Cellular Localisation Secreted
Alternative Protein Names Interleukin-21 protein
Il-21 protein
Za11 protein
IL21 protein

Information sourced from Uniprot.org

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