Human IL1RAP protein (Recombinant-Active) (C-His) (STJP012286)

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STJP012286-100
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human IL1RAP-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: IL1RAP
Gene ID: 3556
Uniprot ID: IL1AP_HUMAN
Immunogen Region: Ser21-Glu359
Immunogen: Homo sapiens (Human)
Function Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone.binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD. May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable). Isoform 2: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B.this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling. Isoform 4: Unable to mediate canonical IL-1 signaling. Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons.
Protein Name Interleukin-1 Receptor Accessory Protein
Il-1 Receptor Accessory Protein
Il-1racp
Interleukin-1 Receptor 3
Il-1r-3
Il-1r3
Database Links Reactome: R-HSA-1257604 Q9NPH3-1
Reactome: R-HSA-388844 Q9NPH3-1
Reactome: R-HSA-6811558 Q9NPH3-1
Reactome: R-HSA-9014826 Q9NPH3-1
Reactome: R-HSA-9014843 Q9NPH3-1
Reactome: R-HSA-9020702 Q9NPH3-1
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Secreted
Isoform 3: Secreted
Alternative Protein Names Interleukin-1 Receptor Accessory Protein protein
Il-1 Receptor Accessory Protein protein
Il-1racp protein
Interleukin-1 Receptor 3 protein
Il-1r-3 protein
Il-1r3 protein
IL1RAP protein
C3orf13 protein
IL1R3 protein

Information sourced from Uniprot.org

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