Human IL16 protein (Recombinant) (N-His) (STJP005372)

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STJP005372
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human IL16-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: IL16
Gene ID: 3603
Uniprot ID: IL16_HUMAN
Immunogen Region: Met1-Val433
Immunogen: Homo sapiens (Human)
Post Translational Modifications Isoform 3: Synthesized as a chemo-attractant inactive precursor in hemopoietic tissues, and proteolytically cleaved by caspase-3 to yield IL-16.
Function Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 1: May act as a scaffolding protein that anchors ion channels in the membrane. Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
Protein Name Pro-Interleukin-16 Cleaved Into - Interleukin-16
Il-16
Lymphocyte Chemoattractant Factor
Lcf
Database Links Reactome: R-HSA-449836
Cellular Localisation Interleukin-16: Secreted
Isoform 1: Cytoplasm
Isoform 3: Cytoplasm
Nucleus
Alternative Protein Names Pro-Interleukin-16 Cleaved Into - Interleukin-16 protein
Il-16 protein
Lymphocyte Chemoattractant Factor protein
Lcf protein
IL16 protein

Information sourced from Uniprot.org

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