Human IL12RB2 protein (Recombinant) (N-His) (STJP005901)

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STJP005901
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human IL12RB2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: IL12RB2
Gene ID: 3595
Uniprot ID: I12R2_HUMAN
Immunogen Region: Trp145-Ala275
Immunogen: Homo sapiens (Human)
Post Translational Modifications On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding.
Function Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
Protein Name Interleukin-12 Receptor Subunit Beta-2
Il-12 Receptor Subunit Beta-2
Il-12r Subunit Beta-2
Il-12r-Beta-2
Il-12rb2
Database Links Reactome: R-HSA-8984722
Reactome: R-HSA-9020591
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Interleukin-12 Receptor Subunit Beta-2 protein
Il-12 Receptor Subunit Beta-2 protein
Il-12r Subunit Beta-2 protein
Il-12r-Beta-2 protein
Il-12rb2 protein
IL12RB2 protein

Information sourced from Uniprot.org

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