Recombinant Human IL-9 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 25-40 KD.

Human IL-9 protein (Recombinant) (STJP003109)

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STJP003109
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Host: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: <0.1 EU/Mu g of the protein by LAL method.
Immunoreactivity: Measured in a cell proliferation assay using M07e human megakaryocytic leukemic cells. The ED50 for this effect is 0.28-1.12 ng/mL, corresponding to a specific activity of 8.9×105~3.6×106 units/mg.
Gene Symbol: IL9
Gene ID: 3578
Uniprot ID: IL9_HUMAN
Immunogen Region: Gln19-Ile144
Immunogen: Recombinant Human IL-9 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln19-Ile144) of human IL9 (Accession #NP_000581.1) fused with and no tag.
Immunogen Sequence: QGCPTLAGILDINFLINKMQ EDPASKCHCSANVTSCLCLG IPSDNCTRPCFSERLSQMTN TTMQTRYPLIFSRVKKSVEV LKNNKCPYFSCEQPCNQTTA GNALTFLKSLLEIFQKEKMR GMRGKI
Function Multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites. Affects intestinal epithelial permeability and adaptive immunity. In addition, induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells. Mechanistically, exerts its biological effects through a receptor composed of IL9R subunit and a signal transducing subunit IL2RG. Receptor stimulation results in the rapid activation of JAK1 and JAK3 kinase activities leading to STAT1, STAT3 and STAT5-mediated transcriptional programs. Induction of differentiation genes seems to be mediated by STAT1 alone, while protection of cells from apoptosis depends on STAT3 and STAT5.
Protein Name Interleukin-9
Il-9
Cytokine P40
T-Cell Growth Factor P40
Database Links Reactome: R-HSA-8985947
Cellular Localisation Secreted
Alternative Protein Names Interleukin-9 protein
Il-9 protein
Cytokine P40 protein
T-Cell Growth Factor P40 protein
IL9 protein

Information sourced from Uniprot.org

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