Human IL-36Ra/IL-1F5 protein (Recombinant) (C-His) (STJP000805)

General Information
Product Properties
Target Information
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Host:	E. coli
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human IL-36Ra/IL-1F5-C-His protein was developed from e. coli and has a target region of C-His. For use in research applications.

Formulation:

Lyophilized from a 0.22 Mu m filtered solution of 20mM TRIS, 150mM NaCl, pH 8.0. Contact us for customized product form or formulation.

Gene Symbol:	IL36RN
Gene ID:	26525
Uniprot ID:	I36RA_HUMAN
Immunogen:	Recombinant Human IL-36Ra/IL-1F5 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Val2-Asp155) of human IL-36Ra (Accession #NP_036407.1) fused with a 6×His tag at the C-terminus.

Tissue Specificity	Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.
Function	Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response.similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.
Protein Name	Interleukin-36 Receptor Antagonist Protein Il-36ra Fil1 Delta Il-1-Related Protein 3 Il-1rp3 Interleukin-1 Hy1 Il-1hy1 Interleukin-1 Delta Il-1 Delta Interleukin-1 Family Member 5 Il-1f5 Interleukin-1 Receptor Antagonist Homolog 1 Il-1ra Homolog 1 Interleukin-1-Like Protein 1 Il-1l1
Database Links	Reactome: R-HSA-9014826
Cellular Localisation	Cytoplasm Secreted The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10 It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion
Alternative Protein Names	Interleukin-36 Receptor Antagonist Protein protein Il-36ra protein Fil1 Delta protein Il-1-Related Protein 3 protein Il-1rp3 protein Interleukin-1 Hy1 protein Il-1hy1 protein Interleukin-1 Delta protein Il-1 Delta protein Interleukin-1 Family Member 5 protein Il-1f5 protein Interleukin-1 Receptor Antagonist Homolog 1 protein Il-1ra Homolog 1 protein Interleukin-1-Like Protein 1 protein Il-1l1 protein IL36RN protein FIL1D protein IL1F5 protein IL1HY1 protein IL1L1 protein IL1RP3 protein UNQ1896 protein PRO4342 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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