Human IL-31RA protein (Recombinant) (C-His) (STJP020299)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human IL-31RA Protein is expressed from Expi293 with His tag at the C-terminal.；It contains Ala20-Glu519.
General Information
| Short Description | Recombinant-Human IL-31RA-C-His protein was developed in hek293 cells using the region Ala20-Glu519. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | IL31RA |
| Gene ID | 133396 |
| Uniprot ID | IL31R_HUMAN |
| Immunogen | Recombinant Human IL-31RA Protein is expressed from Expi293 with His tag at the C-terminal.；It contains Ala20-Glu519. |
| Immunogen Region | Ala20-Glu519 |
Additional Info
| Tissue Specificity | Expressed in CD14- and CD56-positive blood cells. Expressed in macrophages. Expressed in keratinocytes. Expressed in a subset of dorsal root ganglia neurons (at protein level). Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin. Expressed in bronchial and alveolar epithelial cells and pulmonary fibroblasts. Detected in all of the myelomonocytic lineage. Isoform 6: Expressed at higher levels in lesional skin compared to healthy skin of atopic dermatitis patients. |
| Post Translational Modifications | N-glycosylated. |
| Function | Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro. |
| Protein Name | Interleukin-31 Receptor Subunit AlphaIl-31 Receptor Subunit AlphaIl-31r Subunit AlphaIl-31r-AlphaIl-31raCytokine Receptor-Like 3Glm-RHglm-RGp130-Like Monocyte ReceptorGp130-Like ReceptorZcytor17 |
| Database Links | Reactome: R-HSA-6788467 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinPresynaptic Cell MembraneCell ProjectionAxon |
| Alternative Protein Names | Interleukin-31 Receptor Subunit Alpha proteinIl-31 Receptor Subunit Alpha proteinIl-31r Subunit Alpha proteinIl-31r-Alpha proteinIl-31ra proteinCytokine Receptor-Like 3 proteinGlm-R proteinHglm-R proteinGp130-Like Monocyte Receptor proteinGp130-Like Receptor proteinZcytor17 proteinIL31RA proteinCRL3 proteinGPL proteinUNQ6368 proteinPRO21073 proteinPRO21384 protein |
Information sourced from Uniprot.org