| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human IL21R at 2 Mu g/mL (100 Mu L/well) can bind Recombinant Human IL-21 with a linear range of 0.128-5.63 ng/mL. |
| Gene Symbol: | IL21R |
| Gene ID: | 50615 |
| Uniprot ID: | IL21R_HUMAN |
| Immunogen Region: | Cys20-Pro236 |
| Immunogen: | Recombinant Human IL-21R/CD360 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Cys20-Pro236) of human IL-21R/Interleukin-21 Receptor (Accession #NP_068570.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: | CPDLVCYTDYLQTVICILEM WNLHPSTLTLTWQDQYEELK DEATSCSLHRSAHNATHATY TCHMDVFHFMADDIFSVNIT DQSGNYSQECGSFLLAESIK PAPPFNVTVTFSGQYNISWR SDYEDPAFYMLKGKLQYELQ YRNRGDPWAVSPRRKLISVD SRSVSLLPLEFRKDSSYELQ VRAGPMPGSSYQGTWSEWSD PVIFQTQSEELKEGWNP |
| Post Translational Modifications | C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame. |
| Function | This is a receptor for interleukin-21. |
| Protein Name | Interleukin-21 ReceptorIl-21 ReceptorIl-21rNovel Interleukin ReceptorCd Antigen Cd360 |
| Database Links | Reactome: R-HSA-9020958 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-21 Receptor proteinIl-21 Receptor proteinIl-21r proteinNovel Interleukin Receptor proteinCd Antigen Cd360 proteinIL21R proteinNILR proteinUNQ3121 proteinPRO10273 protein |
Information sourced from Uniprot.org