Human IL-1R1/IL-1RT1/CD121a protein (Recombinant) (C-His) (STJP001114)

Human IL-1R1/IL-1RT1/CD121a protein (Recombinant) (C-His) (STJP001114)

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STJP001114
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.1 EU/Mu g of the protein by LAL method.
Immunoreactivity: 1.Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human IL1RA at 5 Mu g/mL (100 Mu L/well) can bind Recombinant Human IL1R1 with a linear range of 63-252 ng/mL.|2.Measured by its binding ability in a functional ELISA. I
Gene Symbol: IL1R1
Gene ID: 3554
Uniprot ID: IL1R1_HUMAN
Immunogen: Recombinant Human IL-1R1/IL-1RT1/CD121a Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp21-Thr332) of human IL1R1 (Accession #NP_000868.1) fused with a 6×His tag at the C-terminus.
Immunogen Sequence: DKCKEREEKIILVSSANEID VRPCPLNPNEHKGTITWYKD DSKTPVSTEQASRIHQHKEK LWFVPAKVEDSGHYYCVVRN SSYCLRIKISAKFVENEPNL CYNAQAIFKQKLPVAGDGGL VCPYMEFFKNENNELPKLQW YKDCKPLLLDNIHFSGVKDR LIVMNVAEKHRGNYTCHASY TYLGKQYPITRVIEFITLEE NKPTRPVIVSPANETMEVDL GSQIQLICNVTGQLSDIAY
Post Translational Modifications A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding). Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.
Function Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells.
Protein Name Interleukin-1 Receptor Type 1
Il-1r-1
Il-1rt-1
Il-1rt1
Cd121 Antigen-Like Family Member A
Interleukin-1 Receptor Alpha
Il-1r-Alpha
Interleukin-1 Receptor Type I
P80
Cd Antigen Cd121a Cleaved Into - Interleukin-1 Receptor Type 1 - Membrane Form
Mil-1r1
Mil-1ri - Interleukin-1 Receptor Type 1 - Soluble Form
Sil-1r1
Sil-1ri
Database Links Reactome: R-HSA-6783783
Reactome: R-HSA-9020702
Reactome: R-HSA-9679191
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Cell Membrane
Secreted
Alternative Protein Names Interleukin-1 Receptor Type 1 protein
Il-1r-1 protein
Il-1rt-1 protein
Il-1rt1 protein
Cd121 Antigen-Like Family Member A protein
Interleukin-1 Receptor Alpha protein
Il-1r-Alpha protein
Interleukin-1 Receptor Type I protein
P80 protein
Cd Antigen Cd121a Cleaved Into - Interleukin-1 Receptor Type 1 - Membrane Form protein
Mil-1r1 protein
Mil-1ri - Interleukin-1 Receptor Type 1 - Soluble Form protein
Sil-1r1 protein
Sil-1ri protein
IL1R1 protein
IL1R protein
IL1RA protein
IL1RT1 protein

Information sourced from Uniprot.org

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