Human IL-1R1/CD121a protein (Recombinant) (C-His) (STJP019912)

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STJP019912-100
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Covered by St John's Laboratory Guarantee

Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Gene Symbol: IL1R1
Gene ID: 3554
Uniprot ID: IL1R1_HUMAN
Immunogen Region: Leu18-Thr332
Immunogen: Recombinant Human IL-1R1/CD121a Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu18-Thr332) of Human IL-1R1/CD121a (Accession #P14778) fused with a C-His tag at the C-terminus.
Immunogen Sequence: LEADKCKEREEKIILVSSAN EIDVRPCPLNPNEHKGTITW YKDDSKTPVSTEQASRIHQH KEKLWFVPAKVEDSGHYYCV VRNSSYCLRIKISAKFVENE PNLCYNAQAIFKQKLPVAGD GGLVCPYMEFFKNENNELPK LQWYKDCKPLLLDNIHFSGV KDRLIVMNVAEKHRGNYTCH ASYTYLGKQYPITRVIEFIT LEENKPTRPVIVSPANETME VDLGSQIQLICNVTGQLSD
Tissue Specificity Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells.
Post Translational Modifications A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding). Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.
Function Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells.
Protein Name Interleukin-1 Receptor Type 1
Il-1r-1
Il-1rt-1
Il-1rt1
Cd121 Antigen-Like Family Member A
Interleukin-1 Receptor Alpha
Il-1r-Alpha
Interleukin-1 Receptor Type I
P80
Cd Antigen Cd121a Cleaved Into - Interleukin-1 Receptor Type 1 - Membrane Form
Mil-1r1
Mil-1ri - Interleukin-1 Receptor Type 1 - Soluble Form
Sil-1r1
Sil-1ri
Database Links Reactome: R-HSA-6783783
Reactome: R-HSA-9020702
Reactome: R-HSA-9679191
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Cell Membrane
Secreted
Alternative Protein Names Interleukin-1 Receptor Type 1 protein
Il-1r-1 protein
Il-1rt-1 protein
Il-1rt1 protein
Cd121 Antigen-Like Family Member A protein
Interleukin-1 Receptor Alpha protein
Il-1r-Alpha protein
Interleukin-1 Receptor Type I protein
P80 protein
Cd Antigen Cd121a Cleaved Into - Interleukin-1 Receptor Type 1 - Membrane Form protein
Mil-1r1 protein
Mil-1ri - Interleukin-1 Receptor Type 1 - Soluble Form protein
Sil-1r1 protein
Sil-1ri protein
IL1R1 protein
IL1R protein
IL1RA protein
IL1RT1 protein

Information sourced from Uniprot.org

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