Human IL-17C (IL-17C) Antibody Pair (STJAP00882)
General Information
| Short Description | This IL-17C antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Clone ID | R09-4F-4/R09-6D-2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purification |
| Dilution Range | Determined by end user |
| Formulation | 0.01M PBS, pH 7.2 |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | IL17C |
| Gene ID | 27189 |
| Uniprot ID | IL17C_HUMAN |
| Immunogen | Recombinant protein |
Additional Info
| Function | Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and pro-inflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases. |
| Protein Name | Interleukin-17cIl-17cCytokine Cx2 |
| Database Links | Reactome: R-HSA-448424 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Interleukin-17c antibody pairIl-17c antibody pairCytokine Cx2 antibody pairIL17C antibody pairUNQ561 antibody pairPRO1122 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human IL-17C (IL-17C) Antibody Pair (STJAP00882)
This antibody pair detects human IL-17C (UniProt Q9P0M4) and is validated for reactivity in human samples only. No cross-reactivity with other species has been stated for this product.
This antibody pair is validated for use in ELISA. It is intended for sandwich ELISA development, with one antibody serving as capture and the other as detection.
Both antibodies are rabbit monoclonal IgGs supplied unconjugated and formulated in 0.01M PBS at pH 7.2. Clone IDs are R09-4F-4 and R09-6D-2, both purified by affinity purification.
Working concentrations are to be determined by the end user. Titration experiments are recommended to establish optimal coating and detection concentrations for the specific assay format and sample type being used.
Both antibodies should be stored at 4°C for short-term use. For long-term storage, aliquot and keep at -20°C. Repeated freeze/thaw cycles should be avoided to maintain antibody integrity.
Both antibodies were raised in rabbit using a recombinant protein immunogen corresponding to human IL-17C. No specific immunogen region is defined in the current product details.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.