Human IL-16 protein (Recombinant) (STJP001874)

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STJP001874

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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human IL-16-protein was developed from hek293. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.2 Mu m filtered PBS solution pH 7.4.
Dilution Range: Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers.
Storage Instruction: Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. NA
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA
Immunoreactivity: The activity was determined by the ability to bind recombinant human CD4 in functional ELISA. NA
Gene Symbol: IL16
Gene ID: 3603
Uniprot ID: IL16_HUMAN
Immunogen Region: Mature chain
Immunogen: DNA sequence encoding mature chain of Human IL16 to a C-terminal polyHis tag was expressed in HEK cells. NA
Tissue Specificity Isoform 3: Expressed in hemopoietic tissues, such as resting T-cells, but undetectable during active T-cell proliferation.
Post Translational Modifications Isoform 3: Synthesized as a chemo-attractant inactive precursor in hemopoietic tissues, and proteolytically cleaved by caspase-3 to yield IL-16.
Function Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 1: May act as a scaffolding protein that anchors ion channels in the membrane. Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
Protein Name Pro-Interleukin-16 Cleaved Into - Interleukin-16
Il-16
Lymphocyte Chemoattractant Factor
Lcf
Database Links Reactome: R-HSA-449836
Cellular Localisation Interleukin-16: Secreted
Isoform 1: Cytoplasm
Isoform 3: Cytoplasm
Nucleus
Alternative Protein Names Pro-Interleukin-16 Cleaved Into - Interleukin-16 protein
Il-16 protein
Lymphocyte Chemoattractant Factor protein
Lcf protein
IL16 protein

Information sourced from Uniprot.org

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