| Host: |
E. coli |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human IL-16-C-His protein was developed from e. coli and has a target region of C-His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of 20mM TRIS, 150mM NaCl, pH 8.0. Contact us for customized product form or formulation. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Recombinant human IL16 at 5 Mu g/mL (100 Mu L/well) can bind Recombinant human CD4 with a linear range of 0.2-1 Mu g/mL. |
| Gene Symbol: |
IL16 |
| Gene ID: |
3603 |
| Uniprot ID: |
IL16_HUMAN |
| Immunogen Region: |
Pro2-Ser130 |
| Immunogen: |
Recombinant Human IL-16 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Pro2-Ser130) of human IL-16 (Accession #NP_757366.2) fused with a 6×His tag at the C-terminus. |
| Tissue Specificity | Isoform 3: Expressed in hemopoietic tissues, such as resting T-cells, but undetectable during active T-cell proliferation. |
| Post Translational Modifications | Isoform 3: Synthesized as a chemo-attractant inactive precursor in hemopoietic tissues, and proteolytically cleaved by caspase-3 to yield IL-16. |
| Function | Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 1: May act as a scaffolding protein that anchors ion channels in the membrane. Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. |
| Protein Name | Pro-Interleukin-16 Cleaved Into - Interleukin-16Il-16Lymphocyte Chemoattractant FactorLcf |
| Database Links | Reactome: R-HSA-449836 |
| Cellular Localisation | Interleukin-16: SecretedIsoform 1: CytoplasmIsoform 3: CytoplasmNucleus |
| Alternative Protein Names | Pro-Interleukin-16 Cleaved Into - Interleukin-16 proteinIl-16 proteinLymphocyte Chemoattractant Factor proteinLcf proteinIL16 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
