| Post Translational Modifications | Phosphorylation controls cell-cycle progression from late G(1) stage to S stage. Hyperphosphorylated during G2/M phase. Dephosphorylated state during late G(1) phase. Phosphorylation on Thr-140 is required for DNA and pericentromeric location during mitosis. CK2 is the main kinase, in vitro. GSK3 and CDK may also contribute to phosphorylation of the C-terminal serine and threonine residues. Phosphorylation on these C-terminal residues reduces the DNA-binding ability. Phosphorylation/dephosphorylation events on Ser-13 and Ser-295 regulate TDT expression during thymocyte differentiation. Dephosphorylation by protein phosphatase 1 regulates stability and pericentromeric heterochromatin location. Phosphorylated in both lymphoid and non-lymphoid tissues. Phosphorylation at Ser-361 and Ser-364 downstream of SYK induces nuclear translocation. Sumoylated. Simultaneous sumoylation on the 2 sites results in a loss of both HDAC-dependent and HDAC-independent repression. Has no effect on pericentromeric heterochromatin location. Desumoylated by SENP1. Polyubiquitinated. |
| Function | Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs). Function is isoform-specific and is modulated by dominant-negative inactive isoforms. |
| Protein Name | Dna-Binding Protein IkarosIkaros Family Zinc Finger Protein 1Lymphoid Transcription Factor Lyf-1 |
| Database Links | Reactome: R-HSA-9013508 Q13422-1 |
| Cellular Localisation | NucleusIn Resting LymphocytesDistributed Diffusely Throughout The NucleusLocalizes To Pericentromeric Heterochromatin In Proliferating CellsThis Localization Requires Dna Binding Which Is Regulated By Phosphorylation / Dephosphorylation EventsIsoform Ik2: NucleusIsoform Ik6: Cytoplasm |
| Alternative Protein Names | Dna-Binding Protein Ikaros proteinIkaros Family Zinc Finger Protein 1 proteinLymphoid Transcription Factor Lyf-1 proteinIKZF1 proteinIK1 proteinIKAROS proteinLYF1 proteinZNFN1A1 protein |
Information sourced from Uniprot.org
