| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
<0.1 EU/Mu g |
| Gene Symbol: |
IGHG3 |
| Uniprot ID: |
IGHG3_HUMAN |
| Immunogen Region: |
Glu99-Lys377 |
| Immunogen: |
Recombinant Human IgG3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu99-Lys377) of human IgG3 (Accession #) fused with no additional amino acid. |
| Immunogen Sequence: |
ELKTPLGDTTHTCPRCPEPK SCDTPPPCPRCPEPKSCDTP PPCPRCPEPKSCDTPPPCPR CPAPELLGGPSVFLFPPKPK DTLMISRTPEVTCVVVDVSH EDPEVQFKWYVDGVEVHNAK TKPREEQYNSTFRVVSVLTV LHQDWLNGKEYKCKVSNKAL PAPIEKTISKTKGQPREPQV YTLPPSREEMTKNQVSLTCL VKGFYPSDIAVEWESSGQPE NNYNTTPPMLDSDGSFFLY |
| Function | Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen. |
| Protein Name | Immunoglobulin Heavy Constant Gamma 3HdcHeavy Chain Disease ProteinIg Gamma-3 Chain C Region |
| Cellular Localisation | Isoform 1: SecretedIsoform 2: Cell MembraneSingle-Pass Membrane Protein |
| Alternative Protein Names | Immunoglobulin Heavy Constant Gamma 3 proteinHdc proteinHeavy Chain Disease Protein proteinIg Gamma-3 Chain C Region proteinIGHG3 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
