| Function | RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD. |
| Protein Name | Insulin-Like Growth Factor 2 Mrna-Binding Protein 2Igf2 Mrna-Binding Protein 2Imp-2Hepatocellular Carcinoma Autoantigen P62Igf-Ii Mrna-Binding Protein 2Vickz Family Member 2 |
| Database Links | Reactome: R-HSA-428359 |
| Cellular Localisation | NucleusCytoplasmP-BodyStress GranuleLocalized In Cytoplasmic Mrnp Granules Containing Untranslated MrnasLocalizes At The Connecting Piece And The Tail Of The SpermatozoaIn Response To Cellular StressSuch As Oxidative StressRecruited To Stress Granules |
| Alternative Protein Names | Insulin-Like Growth Factor 2 Mrna-Binding Protein 2 proteinIgf2 Mrna-Binding Protein 2 proteinImp-2 proteinHepatocellular Carcinoma Autoantigen P62 proteinIgf-Ii Mrna-Binding Protein 2 proteinVickz Family Member 2 proteinIGF2BP2 proteinIMP2 proteinVICKZ2 protein |
Information sourced from Uniprot.org
