Human IFIT1 protein (Recombinant) (N-His) (STJP007566)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human IFIT1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | IFIT1 |
| Gene ID | 3434 |
| Uniprot ID | IFIT1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Pro478 |
Additional Info
| Function | Plays a key role in the innate immune response as part of an interferon-dependent multiprotein complex, recognizing and sequestering viral RNAs that lack host-specific 2'-O-methylation at their 5' cap. By distinguishing these RNAs from host mRNAs, inhibits their translation by competing with the translation initiation factor eIF4E. Could also prevent viral replication through its interaction with DNA replication origin-binding protein E1 of several viruses. Causes the translocation of E1 from the nucleus to the cytoplasm and can also inhibit its helicase activity in vitro. Exhibits antiviral activity against many viruses from the Flaviviridae (West Nile virus, Dengue virus, hepatitis C virus), Coronaviridae (human 229E coronavirus, SARS-CoV-2 and SARS-CoV), Poxviridae (vaccinia virus) and Togaviridae (Sindbis virus) families. |
| Protein Name | Antiviral Innate Immune Response Effector Ifit1Ifit-1Interferon-Induced 56 Kda ProteinIfi-56kP56Interferon-Induced Protein With Tetratricopeptide Repeats 1 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-909733 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Antiviral Innate Immune Response Effector Ifit1 proteinIfit-1 proteinInterferon-Induced 56 Kda Protein proteinIfi-56k proteinP56 proteinInterferon-Induced Protein With Tetratricopeptide Repeats 1 proteinIFIT1 proteinG10P1 proteinIFI56 proteinIFNAI1 proteinISG56 protein |
Information sourced from Uniprot.org