| Function | Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses. |
| Protein Name | Interferon-Induced Protein With Tetratricopeptide Repeats 1Ifit-1Interferon-Induced 56 Kda ProteinIfi-56kP56 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-909733 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Interferon-Induced Protein With Tetratricopeptide Repeats 1 proteinIfit-1 proteinInterferon-Induced 56 Kda Protein proteinIfi-56k proteinP56 proteinIFIT1 proteinG10P1 proteinIFI56 proteinIFNAI1 proteinISG56 protein |
Information sourced from Uniprot.org
