Human IDO1 protein (Recombinant) (N-His) (STJP004116)

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STJP004116
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human IDO1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: IDO1
Gene ID: 3620
Uniprot ID: I23O1_HUMAN
Immunogen Region: Met1-Gly403
Immunogen: Homo sapiens (Human)
Function Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity. Limits the growth of intracellular pathogens by depriving tryptophan. Protects the fetus from maternal immune rejection.
Protein Name Indoleamine 2 -3-Dioxygenase 1
Ido-1
Indoleamine-Pyrrole 2 -3-Dioxygenase
Database Links Reactome: R-HSA-71240
Cellular Localisation Cytoplasm
Cytosol
Alternative Protein Names Indoleamine 2 -3-Dioxygenase 1 protein
Ido-1 protein
Indoleamine-Pyrrole 2 -3-Dioxygenase protein
IDO1 protein
IDO protein
INDO protein

Information sourced from Uniprot.org

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