| Tissue Specificity | |
| Post Translational Modifications | Acetylation at Lys-374 dramatically reduces catalytic activity. |
| Function | Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase. Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways. May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency. |
| Protein Name | Isocitrate Dehydrogenase Nadp CytoplasmicIdhIdh1Cytosolic Nadp-Isocitrate DehydrogenaseIdpcNadp(+-Specific IcdhOxalosuccinate Decarboxylase |
| Database Links | Reactome: R-HSA-2978092Reactome: R-HSA-389542Reactome: R-HSA-6798695Reactome: R-HSA-9033241Reactome: R-HSA-9818025 |
| Cellular Localisation | CytoplasmCytosolPeroxisome |
| Alternative ELISA Names | Isocitrate Dehydrogenase Nadp Cytoplasmic ELISA kitIdh ELISA kitIdh1 ELISA kitCytosolic Nadp-Isocitrate Dehydrogenase ELISA kitIdpc ELISA kitNadp(+-Specific Icdh ELISA kitOxalosuccinate Decarboxylase ELISA kitIDH1 ELISA kitPICD ELISA kit |
| output | |
Information sourced from Uniprot.org
