| Function | Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. |
| Protein Name | Dna-Binding Protein Inhibitor Id-3Class B Basic Helix-Loop-Helix Protein 25Bhlhb25Helix-Loop-Helix Protein Heir-1Id-Like Protein Inhibitor Hlh 1r21Inhibitor Of Dna Binding 3Inhibitor Of Differentiation 3 |
| Database Links | Reactome: R-HSA-9031628 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Dna-Binding Protein Inhibitor Id-3 proteinClass B Basic Helix-Loop-Helix Protein 25 proteinBhlhb25 proteinHelix-Loop-Helix Protein Heir-1 proteinId-Like Protein Inhibitor Hlh 1r21 proteinInhibitor Of Dna Binding 3 proteinInhibitor Of Differentiation 3 proteinID3 protein1R21 proteinBHLHB25 proteinHEIR1 protein |
Information sourced from Uniprot.org
