| Tissue Specificity | Expressed on peripheral blood B-cells and monocytes, as well as on monocyte-derived dendritic cells (at protein level). Isoform 1: Widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil). Isoform 2: Detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells. |
| Post Translational Modifications | |
| Function | Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion. Also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. In endothelial cells, required for proper neutrophil transmigration in response to chemoattractants, such as CXCL8/IL8 or N-formyl-methionyl peptides (fMLP). |
| Protein Name | Icos LigandB7 Homolog 2B7-H2B7-Like Protein Gl50B7-Related Protein 1B7rp-1Cd Antigen Cd275 |
| Database Links | Reactome: R-HSA-388841 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Cell Membrane |
| Alternative ELISA Names | Icos Ligand ELISA kitB7 Homolog 2 ELISA kitB7-H2 ELISA kitB7-Like Protein Gl50 ELISA kitB7-Related Protein 1 ELISA kitB7rp-1 ELISA kitCd Antigen Cd275 ELISA kitICOSLG ELISA kitB7H2 ELISA kitB7RP1 ELISA kitICOSL ELISA kitKIAA0653 ELISA kit |
| output | |
Information sourced from Uniprot.org
