| Host: | HEK293 Cells |
| Applications: | SDS-PAGE |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human Hyaluronidase 1/HYAL1-His-Tag protein was developed from hek293 cells and has a target region of His-Tag. For use in research applications. |
| Formulation: | Liquid in phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol. |
| Concentration: | 0.25 mg/mL |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin: | < 1 EU per 1ug of protein (determined by LAL method) |
| Gene Symbol: | HYAL1 |
| Gene ID: | 3373 |
| Uniprot ID: | HYAL1_HUMAN |
| Immunogen Region: | 22-435aa |
| Accession Number: | NP_149349 |
| Immunogen: | Human |
| Immunogen Sequence: | FRGPLLPNRP FTTVWNANTQ WCLERHGVDV DVSVFDVVAN PGQTFRGPDM TIFYSSQLGT YPYYTPTGEP VFGGLPQNAS LIAHLARTFQ DILAAIPAPD FSGLAVIDWE AWRPRWAFNW DTKDIYRQRS RALVQAQHPD WPAPQVEAVA QDQFQGAARA WMAGTLQLGR ALRPRGLWGF YGFPDCYNYD FLSPNYTGQC PSGIRAQNDQ LGWLWGQSRA LYPSIYMP |
| Tissue Specificity | Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues. |
| Function | May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. |
| Protein Name | Hyaluronidase-1Hyal-1Hyaluronoglucosaminidase-1Lung Carcinoma Protein 1Luca-1 |
| Database Links | Reactome: R-HSA-2024101Reactome: R-HSA-2160916Reactome: R-HSA-2206280 |
| Cellular Localisation | SecretedLysosome |
| Alternative Protein Names | Hyaluronidase-1 proteinHyal-1 proteinHyaluronoglucosaminidase-1 proteinLung Carcinoma Protein 1 proteinLuca-1 proteinHYAL1 proteinLUCA1 protein |
Information sourced from Uniprot.org