Human HTN3 protein (Recombinant) (N-His-KSI) (STJP011172)

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STJP011172
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human HTN3-N-His-KSI protein was developed from e. coli and has a target region of N-His-KSI. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: HTN3
Gene ID: 3347
Uniprot ID: HIS3_HUMAN
Immunogen Region: Asp20-Asn51
Immunogen: Homo sapiens (Human)
Function Histatins are cationic and histidine-rich peptides mainly found in the saliva of higher primates. They are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). Hsts can be divided into two major groups according to their biological functions: antimicrobial Hsts (e.g. Hst 5/HTN3) and cell-activating Hsts (e.g. Hst 1/HTN1, Hst 2/HTN1 and Hst 3/HTN3). Histatin-3: Histatin 3 (Hst 3) is mostly involved in cell migration and wound healing in the oral cavity. Also stimulates cell proliferation after binding to heat shock protein HSC70, which enhances HSC70-CDKN1B complex formation and subsequent ubiquitination during G1/S transition. Also displays antifungal activity against pathogenic yeast Candida albicans, however with less effectiveness than Hst 5. His3-(20-43)-peptide: Histatin 5 (Hst 5), a fragment of Hst 3, is the major histatin exhibiting antifungal and antibacterial activities. It is effective against pathogenic yeast C. albicans, C. neoformans, C. glabrata and S. cerevisiae as well as ESKAPE bacterial pathogens. Secreted Hst 5 mediates a multi-step intracellular mechanism of action against the pathogen. Depending on peptide concentration and pathogen, uptake across the membrane can occur through transporters, direct interaction with plasma membrane and/or receptor-mediated endocytosis. Binds C. albicans cell wall proteins SSA1 and SSA2 and glycans in an energy-independent manner, then is taken up by the cells through fungal polyamine transporters DUR3 and DUR31 in an energy-dependent manner. Internalized Hst5 is then targeted to the energized mitochondrion to induce reactive oxygen species (ROS) formation and subsequent release of intracellular non-lytic ATP which ultimately leads to fungal cell death. In addition, inhibits C. albicans TRK1 potassium-transporter which causes exudation of intracellular K(+), generating an osmotic imbalance leading to delayed membrane lysis and cell death. Also acts as a potent inhibitor of bacterial proteases such as Lys-gingipain and Arg-gingipain (rgpB) from P. gingivalis as well as human metalloproteases MMP2 and MMP9. The binding of metals such as zinc, copper or nickel with Hst 5 results in the protection of the enamel and antimicrobial activities such as the inhibition of microbial growth by decreasing the metal concentration, the formation of ROS commonly associated with redox-active metals, the induction of membrane disruption mediated by zinc binding. Also involved in coating oral surfaces in the form of a salivary film which reduces colonization by C. albicans on epithelial cell surfaces. Secreted Hst 5 can also internalize mammalian epithelial cells and target the mitochondria although it does not exert cytotoxic effects in these cells. In contrast with Hst 3, not able to promote wound healing in mammalian host cells.
Protein Name Histatin-3
Basic Histidine-Rich Protein
Hst
Histatin 3
Hst 3
Histidine-Rich Protein 3
Pb Cleaved Into - Histatin-3 - His3-(20-44-Peptide
His3 20/44
His3-(1-25-Peptide
His3 1/25
Histatin 6
Histatin-3 1/25
Histatin-6 - His3-(20-43-Peptide
His3 20/43
His3-(1-24-Peptide
His3 1/24
Histatin 5
Hst 5
Histatin-3 1/24
Histatin-5 - His3-(20-32-Peptide
His3 20/32
His3-(1-13-Peptide
His3 1/13
Histatin-3 1/13 - His3-(20-31-Peptide
His3 20/31
His3-(1-12-Peptide
His3 1/12
Histatin-3 1/12 - His3-(20-30-Peptide
His3 20/30
His3-(1-11-Peptide
His3 1/11
Histatin-3 1/11 - His3-(24-32-Peptide
His3 24/32
His3-(5-13-Peptide
His3 5/13
Histatin-3 5/13 - His3-(24-31-Peptide
His3 24/31
His3-(5-12-Peptide
His3 5/12
Histatin 11
Histatin-11
Histatin-3 5/12 - His3-(24-30-Peptide
His3 24/30
His3-(5-11-Peptide
His3 5/11
Histatin 12
Histatin-12
Histatin-3 5/11 - His3-(25-32-Peptide
His3 25/32
His3-(6-13-Peptide
His3 6/13
Histatin-3 6/13 - His3-(25-30-Peptide
His3 25/30
His3-(6-11-Peptide
His3 6/11
Histatin-3 6/11 - His3-(26-32-Peptide
His3 26/32
His3-(7-13-Peptide
His3 7/13
Histatin-3 7/13 - His3-(26-31-Peptide
His3 26/31
His3-(7-12-Peptide
His3 7/12
Histatin-3 7/12 - His3-(26-30-Peptide
His3 26/30
His3-(7-11-Peptide
His3 7/11
Histatin-3 7/11 - His3-(31-51-Peptide
His3 31/51
His3-(12-32-Peptide
His3 12/32
Histatin 4
Histatin-3 12/32
Histatin-4 - His3-(31-44-Peptide
His3 31/44
His3-(12-25-Peptide
His3 12/25
Histatin 9
Histatin-3 12/25
Histatin-9 - His3-(31-43-Peptide
His3 31/43
His3-(12-24-Peptide
His3 12/24
Histatin 7
Histatin-3 12/24
Histatin-7 - His3-(32-44-Peptide
His3 32/44
His3-(13-25-Peptide
His3 13/25
Histatin 10
Histatin-10
Histatin-3 13/25 - His3-(32-43-Peptide
His3 32-43
His3-(13-24-Peptide
His3 13/24
Histatin 8
Histatin-3 13/24
Histatin-8 - His3-(33-44-Peptide
His3 33/44
His3-(14-25-Peptide
His3 14/25
Histatin-3 14/25 - His3-(33-43-Peptide
His3 33/43
His3-(14-24-Peptide
His3 14/24
Histatin-3 14/24 - His3-(34-44-Peptide
His3 34/44
His3-(15-25-Peptide
His3 15/25
Histatin-3 15/25 - His3-(34-43-Peptide
His3 34/43
His3-(15-24-Peptide
His3 15/24
Histatin-3 15/24 - His3-(45-51-Peptide
His3 45/51
His3-(26-32-Peptide
His3 26/32
Histatin-3 26/32 - His3-(47-51-Peptide
His3 47/51
His3-(28-32-Peptide
His3 28/32
Histatin-3 28/32 - His3-(48-51-Peptide
His3 48/51
His3-(29-32-Peptide
His3 29/32
Histatin-3 29/32
Database Links Reactome: R-HSA-6803157
Cellular Localisation Secreted
Secreted By Serous Acinar And Demilune Cells
His3-(20-43)-Peptide: Secreted
Mitochondrion
Targeted To Mitochondria In Pathogen Cells After Internalization
Also Localized In The Vacuole In Pathogen Cells
Also Co-Localized With Mitochondria After Internalization In Host Mammalian Cells
Alternative Protein Names Histatin-3 protein
Basic Histidine-Rich Protein protein
Hst protein
Histatin 3 protein
Hst 3 protein
Histidine-Rich Protein 3 protein
Pb Cleaved Into - Histatin-3 - His3-(20-44-Peptide protein
His3 20/44 protein
His3-(1-25-Peptide protein
His3 1/25 protein
Histatin 6 protein
Histatin-3 1/25 protein
Histatin-6 - His3-(20-43-Peptide protein
His3 20/43 protein
His3-(1-24-Peptide protein
His3 1/24 protein
Histatin 5 protein
Hst 5 protein
Histatin-3 1/24 protein
Histatin-5 - His3-(20-32-Peptide protein
His3 20/32 protein
His3-(1-13-Peptide protein
His3 1/13 protein
Histatin-3 1/13 - His3-(20-31-Peptide protein
His3 20/31 protein
His3-(1-12-Peptide protein
His3 1/12 protein
Histatin-3 1/12 - His3-(20-30-Peptide protein
His3 20/30 protein
His3-(1-11-Peptide protein
His3 1/11 protein
Histatin-3 1/11 - His3-(24-32-Peptide protein
His3 24/32 protein
His3-(5-13-Peptide protein
His3 5/13 protein
Histatin-3 5/13 - His3-(24-31-Peptide protein
His3 24/31 protein
His3-(5-12-Peptide protein
His3 5/12 protein
Histatin 11 protein
Histatin-11 protein
Histatin-3 5/12 - His3-(24-30-Peptide protein
His3 24/30 protein
His3-(5-11-Peptide protein
His3 5/11 protein
Histatin 12 protein
Histatin-12 protein
Histatin-3 5/11 - His3-(25-32-Peptide protein
His3 25/32 protein
His3-(6-13-Peptide protein
His3 6/13 protein
Histatin-3 6/13 - His3-(25-30-Peptide protein
His3 25/30 protein
His3-(6-11-Peptide protein
His3 6/11 protein
Histatin-3 6/11 - His3-(26-32-Peptide protein
His3 26/32 protein
His3-(7-13-Peptide protein
His3 7/13 protein
Histatin-3 7/13 - His3-(26-31-Peptide protein
His3 26/31 protein
His3-(7-12-Peptide protein
His3 7/12 protein
Histatin-3 7/12 - His3-(26-30-Peptide protein
His3 26/30 protein
His3-(7-11-Peptide protein
His3 7/11 protein
Histatin-3 7/11 - His3-(31-51-Peptide protein
His3 31/51 protein
His3-(12-32-Peptide protein
His3 12/32 protein
Histatin 4 protein
Histatin-3 12/32 protein
Histatin-4 - His3-(31-44-Peptide protein
His3 31/44 protein
His3-(12-25-Peptide protein
His3 12/25 protein
Histatin 9 protein
Histatin-3 12/25 protein
Histatin-9 - His3-(31-43-Peptide protein
His3 31/43 protein
His3-(12-24-Peptide protein
His3 12/24 protein
Histatin 7 protein
Histatin-3 12/24 protein
Histatin-7 - His3-(32-44-Peptide protein
His3 32/44 protein
His3-(13-25-Peptide protein
His3 13/25 protein
Histatin 10 protein
Histatin-10 protein
Histatin-3 13/25 - His3-(32-43-Peptide protein
His3 32-43 protein
His3-(13-24-Peptide protein
His3 13/24 protein
Histatin 8 protein
Histatin-3 13/24 protein
Histatin-8 - His3-(33-44-Peptide protein
His3 33/44 protein
His3-(14-25-Peptide protein
His3 14/25 protein
Histatin-3 14/25 - His3-(33-43-Peptide protein
His3 33/43 protein
His3-(14-24-Peptide protein
His3 14/24 protein
Histatin-3 14/24 - His3-(34-44-Peptide protein
His3 34/44 protein
His3-(15-25-Peptide protein
His3 15/25 protein
Histatin-3 15/25 - His3-(34-43-Peptide protein
His3 34/43 protein
His3-(15-24-Peptide protein
His3 15/24 protein
Histatin-3 15/24 - His3-(45-51-Peptide protein
His3 45/51 protein
His3-(26-32-Peptide protein
His3 26/32 protein
Histatin-3 26/32 - His3-(47-51-Peptide protein
His3 47/51 protein
His3-(28-32-Peptide protein
His3 28/32 protein
Histatin-3 28/32 - His3-(48-51-Peptide protein
His3 48/51 protein
His3-(29-32-Peptide protein
His3 29/32 protein
Histatin-3 29/32 protein
HTN3 protein
HIS2 protein

Information sourced from Uniprot.org

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