Human HSF2BP protein (Recombinant) (His-Tag) (STJP018880)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human HSF2BP-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 30% Glycerol, 2mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HSF2BP |
| Gene ID | 11077 |
| Uniprot ID | HSF2B_HUMAN |
| Accession Number | NP_008962 |
| Immunogen | Human |
| Immunogen Region | 1-334aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMGEAGAA EEACRHMGTK EEFVKVRKKD LERLTTEVMQ IRDFLPRILN GEVLESFQKL KIVEKNLERK EQELEQLKMD CEHFKARLET VQADNIREKK EKLALRQQLN EAKQQLLQQA EYCTEMGAAA CTLLWGVSSS EEVVKAILGG DKALKFFSIT GQTMESFVKS LDGDVQELDS DESQFVFALA GIVTNVAAIA CGREFLVN |
Additional Info
| Tissue Specificity | Testis specific. Overexpressed in some tumors. |
| Post Translational Modifications | Sumoylated by UBE2I in response to MEKK1-mediated stimuli. |
| Function | Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility. Required for proper recombinase recruitment in female meiosis. Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm. May be involved in modulating HSF2 activation in testis. |
| Protein Name | Heat Shock Factor 2-Binding Protein |
| Database Links | |
| Cellular Localisation | CytoplasmChromosomeLocalizes On Double-Strand Breaks (Dsbs) In Mitotic And Meiotic Chromosomes |
| Alternative Protein Names | Heat Shock Factor 2-Binding Protein proteinHSF2BP proteinMEILB2 protein |
Information sourced from Uniprot.org