Human HSF2BP protein (Recombinant) (His-Tag) (STJP018880)

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STJP018880
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human HSF2BP-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 30% Glycerol, 2mM DTT
Concentration: 0.5 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: HSF2BP
Gene ID: 11077
Uniprot ID: HSF2B_HUMAN
Immunogen Region: 1-334aa
Accession Number: NP_008962
Immunogen: Human
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH MGSMGEAGAA EEACRHMGTK EEFVKVRKKD LERLTTEVMQ IRDFLPRILN GEVLESFQKL KIVEKNLERK EQELEQLKMD CEHFKARLET VQADNIREKK EKLALRQQLN EAKQQLLQQA EYCTEMGAAA CTLLWGVSSS EEVVKAILGG DKALKFFSIT GQTMESFVKS LDGDVQELDS DESQFVFALA GIVTNVAAIA CGREFLVN
Tissue Specificity Testis specific. Overexpressed in some tumors.
Post Translational Modifications Sumoylated by UBE2I in response to MEKK1-mediated stimuli.
Function Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility. Required for proper recombinase recruitment in female meiosis. Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm. May be involved in modulating HSF2 activation in testis.
Protein Name Heat Shock Factor 2-Binding Protein
Database Links
Cellular Localisation Cytoplasm
Chromosome
Localizes On Double-Strand Breaks (Dsbs) In Mitotic And Meiotic Chromosomes
Alternative Protein Names Heat Shock Factor 2-Binding Protein protein
HSF2BP protein
MEILB2 protein

Information sourced from Uniprot.org

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