Tissue Specificity | Widely expressed. Expressed at higher level in lung and brain. Weakly expressed in spleen. |
Post Translational Modifications | N-glycosylated. |
Function | Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes. Required for metanephric development of kidney formation, suggesting that 2-O-sulfation within HS is essential for signaling between ureteric bud and metanephric mesenchyme. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues. |
Protein Name | Heparan Sulfate 2-O-Sulfotransferase 12-O-Sulfotransferase2-Ost2ost |
Database Links | Reactome: R-MMU-2022928 |
Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
Alternative ELISA Names | Heparan Sulfate 2-O-Sulfotransferase 1 ELISA kit2-O-Sulfotransferase ELISA kit2-Ost ELISA kit2ost ELISA kitHs2st1 ELISA kitHs2st ELISA kit |
output | |
Information sourced from Uniprot.org