Function | G-protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter. Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions. |
Protein Name | Histamine H1 ReceptorH1-RH1rHh1r |
Database Links | Reactome: R-HSA-390650Reactome: R-HSA-416476 |
Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
Alternative Protein Names | Histamine H1 Receptor proteinH1-R proteinH1r proteinHh1r proteinHRH1 protein |
Information sourced from Uniprot.org