Function | Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. |
Protein Name | Hematopoietic Prostaglandin D SynthaseH-PgdsGst Class-SigmaGlutathione S-TransferaseGlutathione-Dependent Pgd SynthaseGlutathione-Requiring Prostaglandin D SynthaseProstaglandin-H2 D-Isomerase |
Database Links | Reactome: R-HSA-156590Reactome: R-HSA-2162123 |
Cellular Localisation | Cytoplasm |
Alternative Protein Names | Hematopoietic Prostaglandin D Synthase proteinH-Pgds proteinGst Class-Sigma proteinGlutathione S-Transferase proteinGlutathione-Dependent Pgd Synthase proteinGlutathione-Requiring Prostaglandin D Synthase proteinProstaglandin-H2 D-Isomerase proteinHPGDS proteinGSTS proteinPGDS proteinPTGDS2 protein |
Information sourced from Uniprot.org