Human HP protein (Recombinant) (N-His) (STJP014317)

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STJP014317-100
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Short Description :Recombinant-Human HP-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications.
Applications:ELISA/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Dilution Range:Reconstitute in sterile water for a stock solution.
Formulation:Lyophilized from a 0.22 Mu m filtered solution in 20mM Tris-HCl, 150mM NaCl, 2mM EDTA, 5% Thehalose, pH 8.5.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:< 1 EU/µg as determined by LAL test.
Gene Symbol:HP
Gene ID:3240
Uniprot ID:HPT_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Cys145-Asn406
Function As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
Protein Name Haptoglobin
Zonulin Cleaved Into - Haptoglobin Alpha Chain - Haptoglobin Beta Chain
Database Links Reactome: R-HSA-2168880
Reactome: R-HSA-6798695
Cellular Localisation Secreted
Alternative Protein Names Haptoglobin protein
Zonulin Cleaved Into - Haptoglobin Alpha Chain - Haptoglobin Beta Chain protein
HP protein

Information sourced from Uniprot.org

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