Human HNRNPC protein (Recombinant) (N-His-SUMO) (STJP010834)

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STJP010834
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Covered by St John's Laboratory Guarantee

Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human HNRNPC-N-His-SUMO protein was developed from e. coli and has a target region of N-His-SUMO. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: HNRNPC
Gene ID: 3183
Uniprot ID: HNRPC_HUMAN
Immunogen Region: Ser16-Ala85
Immunogen: Homo sapiens (Human)
Function Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing.
Protein Name Heterogeneous Nuclear Ribonucleoproteins C1/C2
Hnrnp C1/C2
Database Links Reactome: R-HSA-4570464
Reactome: R-HSA-72163
Reactome: R-HSA-72203
Reactome: R-HSA-9013418
Reactome: R-HSA-9013422
Cellular Localisation Nucleus
Component Of Ribonucleosomes
Alternative Protein Names Heterogeneous Nuclear Ribonucleoproteins C1/C2 protein
Hnrnp C1/C2 protein
HNRNPC protein
HNRPC protein

Information sourced from Uniprot.org

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