| Function | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. May bind to specific miRNA hairpins. (Microbial infection) May play a role in HCV RNA replication. (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. |
| Protein Name | Heterogeneous Nuclear Ribonucleoprotein A1Hnrnp A1Helix-Destabilizing ProteinSingle-Strand Rna-Binding ProteinHnrnp Core Protein A1 Cleaved Into - Heterogeneous Nuclear Ribonucleoprotein A1 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-6803529Reactome: R-HSA-72163Reactome: R-HSA-72203Reactome: R-HSA-9692914Reactome: R-HSA-9735869 |
| Cellular Localisation | NucleusCytoplasmLocalized In Cytoplasmic Mrnp Granules Containing Untranslated MrnasShuttles Continuously Between The Nucleus And The Cytoplasm Along With MrnaComponent Of Ribonucleosomes(Microbial Infection) In The Course Of Viral InfectionColocalizes With Hcv Ns5b At Speckles In The Cytoplasm In A Hcv-Replication Dependent Manner(Microbial Infection) Sars Coronavirus-2/Sars-Cov-2 Orf6 Protein Increases Accumulation To The Nucleus |
| Alternative Protein Names | Heterogeneous Nuclear Ribonucleoprotein A1 proteinHnrnp A1 proteinHelix-Destabilizing Protein proteinSingle-Strand Rna-Binding Protein proteinHnrnp Core Protein A1 Cleaved Into - Heterogeneous Nuclear Ribonucleoprotein A1 - N-Terminally Processed proteinHNRNPA1 proteinHNRPA1 protein |
Information sourced from Uniprot.org
