Human HNF1A protein (Recombinant) (N-His) (STJP008766)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human HNF1A-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | HNF1A |
| Gene ID | 6927 |
| Uniprot ID | HNF1A_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr82-Gly288 |
Additional Info
| Post Translational Modifications | Ubiquitinated in s SPOP-dependent manner.leading to prteasomal degradation. |
| Function | Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Activates the transcription of CYP1A2, CYP2E1 and CYP3A11. (Microbial infection) Plays a crucial role for hepatitis B virus gene transcription and DNA replication. Mechanistically, synergistically cooperates with NR5A2 to up-regulate the activity of one of the critical cis-elements in the hepatitis B virus genome enhancer II (ENII). |
| Protein Name | Hepatocyte Nuclear Factor 1-AlphaHnf-1-AlphaHnf-1aLiver-Specific Transcription Factor Lf-B1Lfb1Transcription Factor 1Tcf-1 |
| Database Links | Reactome: R-HSA-210745 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Hepatocyte Nuclear Factor 1-Alpha proteinHnf-1-Alpha proteinHnf-1a proteinLiver-Specific Transcription Factor Lf-B1 proteinLfb1 proteinTranscription Factor 1 proteinTcf-1 proteinHNF1A proteinTCF1 protein |
Information sourced from Uniprot.org