Human HNF1A protein (Recombinant) (N-His) (STJP008766)

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STJP008766
€410.63 - €1,796.88
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human HNF1A-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: HNF1A
Gene ID: 6927
Uniprot ID: HNF1A_HUMAN
Immunogen Region: Thr82-Gly288
Immunogen: Homo sapiens (Human)
Post Translational Modifications Ubiquitinated in s SPOP-dependent manner.leading to prteasomal degradation.
Function Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Activates the transcription of CYP1A2, CYP2E1 and CYP3A11. (Microbial infection) Plays a crucial role for hepatitis B virus gene transcription and DNA replication. Mechanistically, synergistically cooperates with NR5A2 to up-regulate the activity of one of the critical cis-elements in the hepatitis B virus genome enhancer II (ENII).
Protein Name Hepatocyte Nuclear Factor 1-Alpha
Hnf-1-Alpha
Hnf-1a
Liver-Specific Transcription Factor Lf-B1
Lfb1
Transcription Factor 1
Tcf-1
Database Links Reactome: R-HSA-210745
Cellular Localisation Nucleus
Alternative Protein Names Hepatocyte Nuclear Factor 1-Alpha protein
Hnf-1-Alpha protein
Hnf-1a protein
Liver-Specific Transcription Factor Lf-B1 protein
Lfb1 protein
Transcription Factor 1 protein
Tcf-1 protein
HNF1A protein
TCF1 protein

Information sourced from Uniprot.org

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