| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human HMOX1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | HMOX1 |
| Gene ID: | 3162 |
| Uniprot ID: | HMOX1_HUMAN |
| Immunogen Region: | Gln11-Ser229 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | A soluble form arises by proteolytic removal of the membrane anchor. |
| Function | Heme oxygenase 1: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis. Heme oxygenase 1: (Microbial infection) During SARS-COV-2 infection, promotes SARS-CoV-2 ORF3A-mediated autophagy but is unlikely to be required for ORF3A-mediated induction of reticulophagy. Heme oxygenase 1 soluble form: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. |
| Protein Name | Heme Oxygenase 1Ho-1 Cleaved Into - Heme Oxygenase 1 Soluble Form |
| Database Links | Reactome: R-HSA-189483Reactome: R-HSA-6785807Reactome: R-HSA-844456Reactome: R-HSA-917937Reactome: R-HSA-9609523Reactome: R-HSA-9660826Reactome: R-HSA-9707564Reactome: R-HSA-9707587Reactome: R-HSA-9707616Reactome: R-HSA-9818027 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane ProteinCytoplasmic Side |
| Alternative Protein Names | Heme Oxygenase 1 proteinHo-1 Cleaved Into - Heme Oxygenase 1 Soluble Form proteinHMOX1 proteinHO proteinHO1 protein |
Information sourced from Uniprot.org