Human HMGCS (Hydroxymethylglutaryl Coenzyme A Synthase) Sandwich ELISA Kit Kit (STJE0009480)

Human HMGCS (Hydroxymethylglutaryl Coenzyme A Synthase) Sandwich ELISA Kit Kit (STJE0009480)

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STJE0009480
£446.50 - £611.50
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.053ng/mL
Detection Limit: 0.156-10ng/mL
Short Description : This HMGCS Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids..
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: HMGCS2
Gene ID: 3158
Uniprot ID: HMCS2_HUMAN
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Expression in liver is 200-fold higher than in any other tissue. Low expression in colon, kidney, testis, and pancreas. Very low expression in heart and skeletal muscle. Not detected in brain. Isoform 3: Highest expression detected in heart and skeletal muscle.
Post Translational Modifications Succinylated. Desuccinylated by SIRT5. Succinylation, at least at Lys-83 and Lys-310, inhibits the enzymatic activity.
Function Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate.
Protein Name Hydroxymethylglutaryl-Coa Synthase - Mitochondrial
Hmg-Coa Synthase
3-Hydroxy-3-Methylglutaryl Coenzyme A Synthase
Database Links Reactome: R-HSA-1989781
Reactome: R-HSA-77111
Reactome: R-HSA-9837999
Cellular Localisation Mitochondrion
Alternative ELISA Names Hydroxymethylglutaryl-Coa Synthase - Mitochondrial ELISA kit
Hmg-Coa Synthase ELISA kit
3-Hydroxy-3-Methylglutaryl Coenzyme A Synthase ELISA kit
HMGCS2 ELISA kit
output

Information sourced from Uniprot.org

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