Name: Human Hexokinase 2 protein (Recombinant) (His-Tag) (STJP019387)
SKU: STJP019387
Availability: InStock

Human Hexokinase 2 protein (Recombinant) (His-Tag) (STJP019387)

SKU:

STJP019387

£194.50 - £1,710.50

Free Shipping

Host:	E.coli
Applications:	SDS-PAGE/Enzyme Activity
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description :	Recombinant-Human Hexokinase 2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.

Formulation:	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 0.1M NaCl, 0.1mM PMSF
Concentration:	1 mg/mL
Storage Instruction:	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin:	< 1 EU per 1ug of protein (determined by LAL method)
Immunoreactivity:	Specific activity is > 40, 000pmol/min/ug. One unit will convert 1pmole of D-Glucose to D-Glucose-6-phosphate per minute at pH8.0 at 37C.

Gene Symbol:	HK2
Gene ID:	3099
Uniprot ID:	HXK2_HUMAN
Immunogen Region:	1-917aa
Accession Number:	NP_000180
Immunogen:	Human
Immunogen Sequence:	MGSSHHHHHH SSGLVPRGSH MIASHLLAYF FTELNHDQVQ KVDQYLYHMR LSDETLLEIS KRFRKEMEKG LGATTHPTAA VKMLPTFVRS TPDGTEHGEF LALDLGGTNF RVLWVKVTDN GLQKVEMENQ IYAIPEDIMR GSGTQLFDHI AECLANFMDK LQIKDKKLPL GFTFSFPCHQ TKLDESFLVS WTKGFKSSGV EGRDVVALIR KAIQRRGDFD IDIVAVVN

Tissue Specificity	Predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle.
Function	Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis.
Protein Name	Hexokinase-2 Hexokinase Type Ii Hk Ii Hexokinase-B Muscle Form Hexokinase
Database Links	Reactome: R-HSA-70171
Cellular Localisation	Mitochondrion Outer Membrane Peripheral Membrane Protein Cytoplasm Cytosol The Mitochondrial-Binding Peptide (Mbp) Region Promotes Association With The Mitochondrial Outer Membrane The Interaction With The Mitochondrial Outer Membrane Via The Mitochondrial-Binding Peptide (Mbp) Region Promotes Higher Stability Of The Protein Release From The Mitochondrial Outer Membrane Into The Cytosol Induces Permeability Transition Pore (Ptp) Opening And Apoptosis
Alternative Protein Names	Hexokinase-2 protein Hexokinase Type Ii protein Hk Ii protein Hexokinase-B protein Muscle Form Hexokinase protein HK2 protein

Information sourced from Uniprot.org

Human Hexokinase 2 protein (Recombinant) (His-Tag) (STJP019387)

General Information

Model	Name	Host	Application
STJP019671	Human Hexokinase 2 protein (Recombinant) (His-Tag) (STJP019671)	E.coli	SDS-PAGE/Enzyme Activity
STJP019402	Human Hexokinase 4 protein (Recombinant) (His-Tag) (STJP019402)	E.coli	SDS-PAGE/Enzyme Activity
STJP019672	Human Hexokinase 1 protein (Recombinant) (His-Tag) (STJP019672)	E.coli	SDS-PAGE/Enzyme Activity
STJP019670	Human Hexokinase 4 protein (Recombinant) (His-Tag) (STJP019670)	E.coli	SDS-PAGE
STJP019669	Human Hexokinase 3 protein (Recombinant) (His-Tag) (STJP019669)	E.coli	SDS-PAGE