Function | Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway. |
Protein Name | Homocysteine-Responsive Endoplasmic Reticulum-Resident Ubiquitin-Like Domain Member 1 ProteinMethyl MethanesulfonateMmf-Inducible Fragment Protein 1 |
Database Links | Reactome: R-HSA-380994 |
Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
Alternative Protein Names | Homocysteine-Responsive Endoplasmic Reticulum-Resident Ubiquitin-Like Domain Member 1 Protein proteinMethyl Methanesulfonate proteinMmf-Inducible Fragment Protein 1 proteinHERPUD1 proteinHERP proteinKIAA0025 proteinMIF1 protein |
Information sourced from Uniprot.org