| Host: | E.coli |
| Applications: | ELISA/Immunogen/SDS-PAGE/WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human HEPH-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | HEPH |
| Gene ID: | 9843 |
| Uniprot ID: | HEPH_HUMAN |
| Immunogen Region: | Ala24-Cys366 |
| Immunogen: | Homo sapiens (Human) |
| Function | Plasma membrane ferroxidase that mediates the extracellular conversion of ferrous/Fe(2+) iron into its ferric/Fe(3+) form. Couples ferroportin which specifically exports ferrous/Fe(2+) iron from cells to transferrin that only binds and shuttles extracellular ferric/Fe(3+) iron throughout the body. By helping iron transfer from cells to blood mainly contributes to dietary iron absorption by the intestinal epithelium and more generally regulates iron levels in the body. |
| Protein Name | HephaestinHp |
| Database Links | Reactome: R-HSA-425410Reactome: R-HSA-5655799Reactome: R-HSA-917937 |
| Cellular Localisation | Basolateral Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Hephaestin proteinHp proteinHEPH proteinKIAA0698 proteinUNQ2562 proteinPRO6242 protein |
Information sourced from Uniprot.org