Human HCRT protein (Recombinant) (N-His) (STJP003288)

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STJP003288
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human HCRT-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: HCRT
Gene ID: 3060
Uniprot ID: OREX_HUMAN
Immunogen Region: Gln34-Met97
Immunogen: Homo sapiens (Human)
Post Translational Modifications Specific enzymatic cleavages at paired basic residues yield the different active peptides.
Function Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A: Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity. Stimulates food intake. Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner. Orexin-B: Binds to orexin receptor HCRTR2/OX2R only. Stimulates food intake. Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner.
Protein Name Hypocretin Neuropeptide Precursor
Hypocretin
Hcrt
Orexin Precursor
Prepro-Orexin
Preprohypocretin Cleaved Into - Orexin-A
Hypocretin-1
Hcrt1 - Orexin-B
Hypocretin-2
Hcrt2
Database Links Reactome: R-HSA-389397
Reactome: R-HSA-416476
Cellular Localisation Rough Endoplasmic Reticulum
Cytoplasmic Vesicle
Synapse
Associated With Perikaryal Rough Endoplasmic Reticulum As Well As Cytoplasmic Large Granular Vesicles At Synapses
Alternative Protein Names Hypocretin Neuropeptide Precursor protein
Hypocretin protein
Hcrt protein
Orexin Precursor protein
Prepro-Orexin protein
Preprohypocretin Cleaved Into - Orexin-A protein
Hypocretin-1 protein
Hcrt1 - Orexin-B protein
Hypocretin-2 protein
Hcrt2 protein
HCRT protein
OX protein
PPORX protein
PPOX protein

Information sourced from Uniprot.org

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