Human HCN2 protein (Recombinant) (N-His) (STJP008374)

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STJP008374
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human HCN2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: HCN2
Gene ID: 610
Uniprot ID: HCN2_HUMAN
Immunogen Region: Gly524-Leu713
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylation at Ser-668 by PRKG2 shifts the voltage-dependence to more negative voltages, hence counteracting the stimulatory effect of cGMP on gating. S-palmitoylated. N-glycosylated.required for cell surface trafficking of HCN2.
Function Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Involved in the initiation of neuropathic pain in sensory neurons.
Protein Name Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2
Brain Cyclic Nucleotide-Gated Channel 2
Bcng-2
Database Links Reactome: R-HSA-1296061
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Protein Names Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 protein
Brain Cyclic Nucleotide-Gated Channel 2 protein
Bcng-2 protein
HCN2 protein
BCNG2 protein

Information sourced from Uniprot.org

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