Human HBS1L protein (Recombinant) (N-His) (STJP008773)

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STJP008773
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human HBS1L-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: HBS1L
Gene ID: 10767
Uniprot ID: HBS1L_HUMAN
Immunogen Region: Gly257-Lys478
Immunogen: Homo sapiens (Human)
Function GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.
Protein Name Hbs1-Like Protein
Erfs
Database Links Reactome: R-HSA-429958
Cellular Localisation Cytoplasm
Isoform 2: Cytoplasm
Alternative Protein Names Hbs1-Like Protein protein
Erfs protein
HBS1L protein
HBS1 protein
KIAA1038 protein

Information sourced from Uniprot.org

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