Function | GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. |
Protein Name | Hbs1-Like ProteinErfs |
Database Links | Reactome: R-HSA-429958 |
Cellular Localisation | CytoplasmIsoform 2: Cytoplasm |
Alternative Protein Names | Hbs1-Like Protein proteinErfs proteinHBS1L proteinHBS1 proteinKIAA1038 protein |
Information sourced from Uniprot.org